{"id":480,"date":"2026-10-22T11:30:00","date_gmt":"2026-10-22T03:30:00","guid":{"rendered":"https:\/\/www.ivd-stage.com\/?p=480"},"modified":"2026-10-21T21:55:09","modified_gmt":"2026-10-21T13:55:09","slug":"%e6%89%8e%e4%b8%80%e4%b8%8b%e6%89%8b%e6%8c%87%e6%b5%8b%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%ef%bc%8cnfl-%e7%9b%b8%e5%85%b3%e6%80%a7-0-91%ef%bc%8cptau217-%e5%8f%aa%e6%9c%89-0-23%ef%bc%81","status":"publish","type":"post","link":"https:\/\/www.ivd-stage.com\/index.php\/2026\/10\/22\/%e6%89%8e%e4%b8%80%e4%b8%8b%e6%89%8b%e6%8c%87%e6%b5%8b%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%ef%bc%8cnfl-%e7%9b%b8%e5%85%b3%e6%80%a7-0-91%ef%bc%8cptau217-%e5%8f%aa%e6%9c%89-0-23%ef%bc%81\/","title":{"rendered":"\u624e\u4e00\u4e0b\u624b\u6307\u6d4b\u963f\u5c14\u8328\u6d77\u9ed8\uff0cNfL \u76f8\u5173\u6027 0.91\uff0cpTau217 \u53ea\u6709 0.23\uff01"},"content":{"rendered":"<p><!-- IVD-STAGE \u516c\u4f17\u53f7\u6392\u7248\u6a21\u677f\uff08\u5185\u8054\u6837\u5f0f\uff0c\u517c\u5bb9\u5fae\u4fe1\uff09\n\u53d8\u91cf\u5360\u4f4d\u7b26\uff08\u63a8\u9001\u811a\u672c\u4f1a\u66ff\u6362\uff09\uff1a\n  \u624e\u4e00\u4e0b\u624b\u6307\u6d4b\u963f\u5c14\u8328\u6d77\u9ed8\uff0cNfL \u76f8\u5173\u6027 0.91\uff0cpTau217 \u53ea\u6709 0.23\uff01        \u6587\u7ae0\u6807\u9898\n  [CONTENT]        \u6b63\u6587 HTML\uff08\u7531 markdown \u8f6c\u6362\u5f97\u5230\uff09\n           \u53d1\u5e03\u65e5\u671f 2026\u5e748\u670811\u65e5\n      \u6587\u672b\u7f72\u540d\/\u547c\u544a\uff08\u53ef\u9009\uff09\n  {{RELATED_1..4}} \u5f80\u671f\u63a8\u8350 \u6807\u9898|\u94fe\u63a5 \uff08\u6bcf\u671f\u6362\uff0c\u53ef\u5c11\u586b\uff09\n--><\/p>\n<div style=\"font-family:-apple-system,'PingFang SC','Microsoft YaHei',sans-serif;color:#2b2b2b;font-size:15px;line-height:2;letter-spacing:0.5px;\">\n<p>  <!-- \u6b63\u6587 --><\/p>\n<section style=\"margin:0;padding:16px 8px;background:#f7f8fa;border-radius:8px;\">\n<blockquote style=\"background:#f6f8fb;border-left:4px solid #1f3a5f;margin:14px 0;padding:10px 14px;color:#555;font-size:15px;\"><p>2026 \u5e74 10 \u6708 16 \u65e5\uff0c\u7ea6\u7ff0\u65af\u00b7\u970d\u666e\u91d1\u65af\u56e2\u961f\u5728 *Annals of Clinical and Translational Neurology* \u5728\u7ebf\u53d1\u8868\uff0c<strong>192 \u4f4d\u60a3\u8005<\/strong>\u540c\u65f6\u7559\u8111\u810a\u6db2\u3001\u9759\u8109\u8840\u548c\u6307\u5c16\u8840\uff08TAPII\u3001Tasso+ \u4e24\u79cd\u91c7\u8840\u88c5\u7f6e\uff09\uff0c\u56db\u4e2a\u963f\u5c14\u8328\u6d77\u9ed8\u8840\u6807\u9010\u4e00\u5bf9\u6bd4\u3002<strong>NfL\u3001GFAP\u3001A\u03b242\/40 \u8ddf\u9759\u8109\u8840\u9ad8\u5ea6\u4e00\u81f4\uff0cpTau217 \u53ea\u6709 r=0.23\uff0c\u6d53\u5ea6\u9ad8\u51fa\u8fd1 30 \u500d\u3002<\/strong><\/p><\/blockquote>\n<p style=\"margin:14px 0;text-align:justify;\"><img decoding=\"async\" src=\"https:\/\/www.ivd-stage.com\/wp-content\/uploads\/2026\/10\/acn_20261021214844.png\" style=\"max-width:100%;border-radius:4px;margin:8px 0;\" alt=\"\"\/><\/p>\n<p style=\"border-top:1px solid #e3e8ef;margin:22px 0;\">\n<h2 style=\"color:#1f3a5f;font-size:16px;font-weight:bold;margin:20px 0 10px;\">\u5982\u4f55\u91c7\u6837<\/h2>\n<p style=\"margin:14px 0;text-align:justify;\">2021 \u5e74 10 \u6708\u5230 2024 \u5e74 4 \u6708\uff0c\u5728\u7ea6\u7ff0\u65af\u00b7\u970d\u666e\u91d1\u65af\u8111\u810a\u6db2\u75be\u75c5\u4e2d\u5fc3\u505a\u8170\u7a7f\u7684\u60a3\u8005\uff0c\u4e00\u5171 <strong>192 \u4eba<\/strong>\uff0c\u5e73\u5747 <strong>61 \u5c81<\/strong>\uff0c\u8de8\u5ea6 16 \u5230 91 \u5c81\u3002<\/p>\n<p style=\"margin:14px 0;text-align:justify;\">\u8bca\u65ad\u5206\u516d\u7ec4\uff1a\u5e74\u8f7b\u6b63\u5e38 25 \u4eba\u3001\u8001\u5e74\u6b63\u5e38 11 \u4eba\u3001\u6b63\u5e38\u538b\u529b\u8111\u79ef\u6c34 42 \u4eba\u3001\u963f\u5c14\u8328\u6d77\u9ed8 25 \u4eba\u3001\u8840\u7ba1\u6027\u75f4\u5446 28 \u4eba\u3001\u5176\u4ed6\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5 61 \u4eba\u3002<\/p>\n<p style=\"margin:14px 0;text-align:justify;\">CSF \u6536\u5230 <strong>191 \u4efd<\/strong>\u3001\u9759\u8109\u8840\u6d46 <strong>169 \u4efd<\/strong>\u3001TAPII \u6307\u5c16\u8840\u6d46 <strong>86 \u4efd<\/strong>\u3001Tasso+ \u6307\u5c16\u8840\u6d46 <strong>126 \u4efd<\/strong>\uff0c\u5176\u4e2d <strong>20 \u4eba\u4e24\u79cd\u88c5\u7f6e\u90fd\u91c7\u4e86<\/strong>\u3002\u91c7\u6307\u5c16\u8840\u524d\u4e0a\u81c2\u70ed\u6577 <strong>5 \u5206\u949f<\/strong>\uff0c\u88c5\u7f6e\u8d34\u4e0a\u540e\u91c7\u8840 <strong>5 \u5206\u949f<\/strong>\uff0c\u4e24\u79cd\u88c5\u7f6e\u90fd\u7528 EDTA \u6297\u51dd\u3002<\/p>\n<p style=\"margin:14px 0;text-align:justify;\">\u68c0\u6d4b\u7cfb\u7edf\u4f7f\u7528 Quanterix Simoa HD-X\uff0cGFAP\u3001NfL\u3001A\u03b240\u3001A\u03b242 \u7528 Neurology 4-Plex E\uff0cpTau217 \u5355\u72ec\u7528 ALZpath \u8bd5\u5242\u76d2\uff0c\u5168\u90e8\u5355\u5b54\u3002\u6279\u95f4 CV \u4ece <strong><7%\uff08pTau217\uff09\u5230 <12%\uff08GFAP\uff09<\/strong>\u3002<\/p>\n<p style=\"margin:14px 0;text-align:justify;\">\u5b9e\u9645\u91c7\u5230\u7684\u8840\u91cf\u503c\u5f97\u4e00\u63d0\u3002Tasso+ \u5e73\u5747\u91c7\u8840\u91cf <strong>294 \u03bcL<\/strong>\uff0cTAPII \u4e3a <strong>267 \u03bcL<\/strong>\uff0c\u800c\u5382\u5bb6\u5ba3\u79f0\u7684\u662f <strong>350 \u5230 600 \u03bcL<\/strong>\u3002<\/p>\n<p style=\"margin:14px 0;text-align:justify;\"><img decoding=\"async\" src=\"https:\/\/www.ivd-stage.com\/wp-content\/uploads\/2026\/10\/acn_20261021214935.png\" style=\"max-width:100%;border-radius:4px;margin:8px 0;\" alt=\"\"\/><\/p>\n<p style=\"border-top:1px solid #e3e8ef;margin:22px 0;\">\n<h2 style=\"color:#1f3a5f;font-size:16px;font-weight:bold;margin:20px 0 10px;\">\u91c7\u6837\u8212\u9002\u5ea6<\/h2>\n<p style=\"margin:14px 0;text-align:justify;\">\u75bc\u75db\u7528 0 \u5230 10 \u5206\u6253\u5206\u3002\u9759\u8109\u7a7f\u523a <strong>2.24<\/strong>\uff0cTAPII <strong>0.73<\/strong>\uff0cTasso+ <strong>0.2<\/strong>\uff0c\u4e09\u7ec4\u4e24\u4e24\u4e4b\u95f4\u5168 p<0.001\u3002<\/p>\n<p style=\"margin:14px 0;text-align:justify;\">\u6eb6\u8840\u8bc4\u5206 TAPII <strong>2.08\/4<\/strong>\u3001Tasso+ <strong>1.37\/4<\/strong>\uff08p<0.001\uff09\u3002<\/p>\n<p style=\"margin:14px 0;text-align:justify;\">\u4f5c\u8005\u628a\u8fd9\u79cd\u5dee\u5f02\u7684\u4e3b\u8981\u539f\u56e0\u5f52\u5230\u4e24\u79cd\u91c7\u6837\u5668\u4f7f\u7528\u7684\u9488\u4e0a\uff0cTAPII \u662f <strong>16 \u6839 500 \u03bcm \u5fae\u9488<\/strong>\u9635\u5217\uff0cTasso+ \u662f<strong>\u5355\u6839 5 mm \u9488<\/strong>\u3002<\/p>\n<p style=\"border-top:1px solid #e3e8ef;margin:22px 0;\">\n<h2 style=\"color:#1f3a5f;font-size:16px;font-weight:bold;margin:20px 0 10px;\">\u4e09\u9879\u8fc7\u5173<\/h2>\n<p style=\"margin:14px 0;text-align:justify;\">\u8ddf\u540c\u4e00\u6b21\u91c7\u7684\u9759\u8109\u8840\u6d46\u6bd4\u3002<\/p>\n<p style=\"margin:14px 0;text-align:justify;\">TAPII \u7684 NfL r=<strong>0.86<\/strong>\u3001GFAP r=<strong>0.84<\/strong>\u3001A\u03b242\/40 r=<strong>0.74<\/strong>\uff1b<\/p>\n<p style=\"margin:14px 0;text-align:justify;\">Tasso+ \u7684 NfL r=<strong>0.91<\/strong>\u3001GFAP r=<strong>0.80<\/strong>\u3001A\u03b242\/40 r=<strong>0.75<\/strong>\uff0c\u5168\u90e8 p<0.001\u3002<\/p>\n<p style=\"margin:14px 0;text-align:justify;\">\u7ec4\u5185\u76f8\u5173\u7cfb\u6570\uff0cTasso+ \u7684 GFAP <strong>0.89<\/strong>\u3001A\u03b242\/40 <strong>0.84<\/strong>\u3001NfL <strong>0.80<\/strong>\uff1bTAPII \u7684 NfL <strong>0.84<\/strong>\u3001A\u03b242\/40 <strong>0.74<\/strong>\u3001GFAP <strong>0.69<\/strong>\u3002<\/p>\n<p style=\"border-top:1px solid #e3e8ef;margin:22px 0;\">\n<h2 style=\"color:#1f3a5f;font-size:16px;font-weight:bold;margin:20px 0 10px;\">pTau217 \u4e0d\u884c<\/h2>\n<p style=\"margin:14px 0;text-align:justify;\">Tasso+ \u7684\u6307\u5c16 pTau217 \u4e0e\u9759\u8109\u53ea\u6709 <strong>r=0.23\uff08p=0.04\uff09<\/strong>\uff0cTAPII \u5e72\u8106\u4e0d\u663e\u8457\uff08p=0.12\uff09\uff0c\u76f8\u5173\u6027\u90fd\u975e\u5e38\u5dee\u3002<\/p>\n<p style=\"margin:14px 0;text-align:justify;\">\u6307\u5c16\u8840\u5bf9\u9759\u8109\u8840\u6d46\u662f\u7cfb\u7edf\u6027\u6b63\u504f\u501a\uff0c\u5e73\u5747 <strong>+7 pg\/mL\uff08TAPII\uff09<\/strong>\u3001<strong>+3 pg\/mL\uff08Tasso+\uff09<\/strong>\uff0c\u800c\u4e14\u6d53\u5ea6\u8d8a\u9ad8\u5dee\u5f97\u8d8a\u591a\u3002<\/p>\n<p style=\"margin:14px 0;text-align:justify;\">\u6362\u7b97\u4e0b\u6765\uff0c<strong>TAPII \u6bd4\u9759\u8109\u9ad8\u8fd1 30 \u500d\uff0cTasso+ \u9ad8 10 \u500d\uff0cTAPII \u53c8\u6bd4 Tasso+ \u9ad8 3 \u500d<\/strong>\u3002<\/p>\n<p style=\"margin:14px 0;text-align:justify;\">Passing\u2013Bablok \u4ee5\u9759\u8109\u4e3a\u53c2\u7167\uff0cTAPII \u7684\u659c\u7387\u662f <strong>218.9\uff0895% CI 109.2\u20131351.3\uff09<\/strong>\uff0cTasso+ \u662f <strong>25.4\uff0814.9\u201341.8\uff09<\/strong>\u3002<\/p>\n<p style=\"margin:14px 0;text-align:justify;\">\u6587\u732e\u4e2d\u5f15\u7528\u7684\u63d0\u793a\u8111\u5185\u6dc0\u7c89\u6837\u75c5\u7406\u7684\u521d\u6b65 cutoff \u662f <strong>0.42 pg\/mL<\/strong>\uff0c\u4e24\u79cd\u6307\u5c16\u88c5\u7f6e\u6d4b\u51fa\u6765\u7684\u6837\u672c\uff0c<strong>95% \u90fd\u8d8a\u8fc7\u4e86\u8fd9\u6761\u7ebf<\/strong>\u3002<\/p>\n<p style=\"margin:14px 0;text-align:justify;\">\u5065\u5eb7\u5e74\u8f7b\u4eba\u7ec4\u4e2d\uff0c\u9759\u8109\u8840 pTau217 \u5747\u503c <strong>0.18 pg\/mL<\/strong>\uff0c\u800c TAPII \u6d4b\u51fa\u6765 <strong>6.94<\/strong>\u3001Tasso+ <strong>4.34<\/strong>\u3002<\/p>\n<p style=\"margin:14px 0;text-align:justify;\">\u4f5c\u8005\u7ed9\u51fa\u4e24\u4e2a\u731c\u6d4b\u3002\u4e00\u662f\u76ae\u80a4\u5916\u5468\u795e\u7ecf\u672b\u68a2\u91cc\u672c\u6765\u5c31\u6709\u78f7\u9178\u5316 tau \u548c \u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u805a\u96c6\u4f53\uff0c\u91c7\u8840\u88c5\u7f6e\u53ef\u80fd\u628a\u5916\u5468 pTau217 \u4e00\u8d77\u5e26\u8fdb\u4e86\u6837\u672c\uff1b\u4e8c\u662f\u57fa\u8d28\u6548\u5e94\u3002<\/p>\n<p style=\"border-top:1px solid #e3e8ef;margin:22px 0;\">\n<h2 style=\"color:#1f3a5f;font-size:16px;font-weight:bold;margin:20px 0 10px;\">\u5bf9\u6bd4\u8111\u810a\u6db2<\/h2>\n<p style=\"margin:14px 0;text-align:justify;\">\u9759\u8109\u8840\u91cc NfL\uff08r=<strong>0.73<\/strong>\uff09\u3001GFAP\uff08<strong>0.59<\/strong>\uff09\u3001pTau217\uff08<strong>0.33<\/strong>\uff09\u90fd\u4e0e CSF \u663e\u8457\u76f8\u5173\uff0cA\u03b242\/40 \u4e0d\u76f8\u5173\uff08p=0.169\uff09\u3002<\/p>\n<p style=\"margin:14px 0;text-align:justify;\">\u5230\u4e86\u6307\u5c16\u8840\uff0c\u53ea\u5269 NfL\uff08TAPII <strong>0.74<\/strong>\u3001Tasso+ <strong>0.69<\/strong>\uff09\u548c GFAP\uff08TAPII <strong>0.6<\/strong>\u3001Tasso+ <strong>0.59<\/strong>\uff09\u8fd8\u5bf9\u5f97\u4e0a\uff0cA\u03b242\/40 \u548c pTau217 \u90fd\u4e0d\u76f8\u5173\u3002<\/p>\n<p style=\"border-top:1px solid #e3e8ef;margin:22px 0;\">\n<p style=\"margin:14px 0;text-align:justify;\"><strong>\u5c45\u5bb6\u81ea\u91c7\u6d4b\u963f\u5c14\u8328\u6d77\u9ed8\uff0c\u770b\u6765\u8fd8\u6709\u5f88\u957f\u7684\u8def\u8981\u8d70\uff01<\/strong><\/p>\n<blockquote style=\"background:#f6f8fb;border-left:4px solid #1f3a5f;margin:14px 0;padding:10px 14px;color:#555;font-size:15px;\"><p>Ho S, Shen Z, Lewis A, et al. Alzheimer&#8217;s Disease Biomarkers Measured by Capillary Blood Collection Versus Venous Plasma and Cerebrospinal Fluid. *Annals of Clinical and Translational Neurology*. 2026;0:1\u201313. DOI: 10.1002\/acn3.70524<\/p><\/blockquote>\n<p style=\"border-top:1px solid #e3e8ef;margin:22px 0;\">\n<p style=\"margin:14px 0;text-align:justify;\"><strong>\u514d\u8d23\u58f0\u660e<\/strong><\/p>\n<p style=\"margin:14px 0;text-align:justify;\">\u672c\u6587\u57fa\u4e8e\u516c\u5f00\u4fe1\u606f\u4e0e\u5df2\u53d1\u8868\u6587\u732e\u6574\u7406\uff0c\u4ec5\u4ee3\u8868\u4f5c\u8005\u4e2a\u4eba\u89c2\u70b9\uff0c<strong>\u4e0d\u6784\u6210\u4efb\u4f55\u6295\u8d44\u5efa\u8bae<\/strong>\uff1b\u6d89\u53ca\u4e0a\u5e02\u516c\u53f8\u7684\u5185\u5bb9\u5747\u5f15\u81ea\u5176\u516c\u5f00\u62ab\u9732\u6587\u4ef6\uff0c\u4e0d\u4ee3\u8868\u5bf9\u8be5\u516c\u53f8\u8bc1\u5238\u4ef7\u503c\u6216\u7ecf\u8425\u524d\u666f\u7684\u4efb\u4f55\u5224\u65ad\u3002\u6587\u4e2d\u4ea7\u54c1\u4e0e\u6280\u672f\u4fe1\u606f\u4ec5\u4f9b\u884c\u4e1a\u4ea4\u6d41\uff0c<strong>\u4e0d\u6784\u6210\u533b\u7597\u5efa\u8bae\u3001\u8bca\u65ad\u4f9d\u636e\u6216\u4ea7\u54c1\u63a8\u8350<\/strong>\u3002\u5982\u6709\u4e8b\u5b9e\u51fa\u5165\uff0c\u6b22\u8fce\u6307\u6b63\u5e76\u4f9d\u89c4\u66f4\u6b63\u3002<\/p>\n<\/section>\n<p>  <!-- \u6587\u672b\u547c\u544a --><\/p>\n<p style=\"margin:28px 0 8px;color:#1f3a5f;font-weight:bold;font-size:17px;\">\n<p>  <!-- 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