{"id":295,"date":"2026-09-07T07:30:00","date_gmt":"2026-09-06T23:30:00","guid":{"rendered":"https:\/\/www.ivd-stage.com\/?p=295"},"modified":"2026-09-06T13:53:40","modified_gmt":"2026-09-06T05:53:40","slug":"9%e4%b8%aa%e5%8e%82%e5%ae%b6%e7%9a%84p-tau217%e6%a3%80%e6%b5%8b%e8%af%95%e5%89%82%e7%9b%92%e5%90%8c%e5%8f%b0%e6%89%93%e6%93%82%ef%bc%8c%e4%b8%a4%e5%ae%b6%e5%bd%93%e5%9c%ba%e6%8e%89%e9%98%9f%ef%bc%81","status":"publish","type":"post","link":"https:\/\/www.ivd-stage.com\/index.php\/2026\/09\/07\/9%e4%b8%aa%e5%8e%82%e5%ae%b6%e7%9a%84p-tau217%e6%a3%80%e6%b5%8b%e8%af%95%e5%89%82%e7%9b%92%e5%90%8c%e5%8f%b0%e6%89%93%e6%93%82%ef%bc%8c%e4%b8%a4%e5%ae%b6%e5%bd%93%e5%9c%ba%e6%8e%89%e9%98%9f%ef%bc%81\/","title":{"rendered":"9\u4e2a\u5382\u5bb6\u7684p-tau217\u68c0\u6d4b\u8bd5\u5242\u76d2\u540c\u53f0\u6253\u64c2\uff0c\u4e24\u5bb6\u5f53\u573a\u6389\u961f\uff01"},"content":{"rendered":"

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\u4e2d\u79d1\u5927\u65bd\u70af\u56e2\u961f\u5728Science Bulletin\u4e0a\u53d1\u8868CLEAR-AD\u7814\u7a76\uff0c\u5168\u56fd10\u5bb6\u8bb0\u5fc6\u95e8\u8bca\u3001431\u4f8b\u3001\u540c\u4e00\u6b21\u91c7\u8840\u3001\u76f2\u6cd5\u5934\u5bf9\u5934\u6bd4\u8f839\u79cd\u5546\u4e1a\u5316\u8840\u6d46p-tau217\u68c0\u6d4b\u3002<\/p><\/blockquote>\n

p-tau217\u662f\u5f53\u4e0bAD\u8840\u68c0\u6700\u706b\u7684\u6807\u5fd7\u7269\u30022025\u5e74FDA\u6279\u51c6\u4e86\u7b2c\u4e00\u6b3eAD\u8840\u68c0\u4ea7\u54c1\uff0cFujirebio\u7684Lumipulse G pTau217\/\u03b2-Amyloid 1-42 Plasma Ratio\u3002\u4e34\u5e8a\u6307\u5357\u63a8\u8350\u786e\u8bc1\u573a\u666f\u4e0b\u7075\u654f\u5ea6\/\u7279\u5f02\u5ea6\u81f3\u5c11\u8fbe\u523090%\uff0c\u8840\u68c0\u624d\u80fd\u5e73\u66ffPET\u548c\u8111\u810a\u6db2\u3002<\/p>\n

\u95ee\u9898\u662f\uff0c\u4e0d\u540c\u6297\u4f53\u3001\u4e0d\u540c\u6821\u51c6\u54c1\u3001\u4e0d\u540c\u5e73\u53f0\uff0c\u6027\u80fd\u5dee\u591a\u5c11\uff1f<\/p>\n

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\u7814\u7a76\u65b9\u6cd5<\/h2>\n

\u5171\u6709\u6837\u672c511\u4f8b\u5165\u7ec4\uff0c431\u4f8b\u7b26\u5408\u8981\u6c42\u7684\u8840\u6db2\u6837\u672c\u8fdb\u5165\u5206\u6790\uff0c\u4e2d\u4f4d\u5e74\u9f8468.0\u5c81\uff0c\u5973\u6027\u5360\u6bd461.7%\uff0c64.0%\uff08276\u4f8b\uff09\u7684A\u03b2-PET\u7ed3\u679c\u4e3a\u9633\u6027\uff1b\u8ba4\u77e5\u672a\u635f30\u4f8b\u3001MCI 230\u4f8b\u3001\u75f4\u5446171\u4f8b\uff0cAPOE \u03b54\u643a\u5e26\u738745.5%\u3002<\/p>\n

9\u79cd\u5546\u4e1a\u5316\u8bd5\u5242\u8986\u76d6\u4e86\u4e09\u6761\u6280\u672f\u8def\u7ebf\uff1a\u5316\u5b66\u53d1\u5149\uff08Fujirebio\u3001Beckman Coulter\u3001Vazyme\u3001\u5382\u5bb6A\uff09\u3001\u5355\u5206\u5b50\u514d\u75ab\uff08Quanterix\u3001Lychix\u3001iomicsBio\u3001\u5382\u5bb6B\uff09\u3001\u591a\u91cd\u5fae\u7403\u6d41\u5f0f\uff08CellGene\uff09\uff0c\u5176\u4e2d6\u79cd\u540c\u65f6\u6d4bA\u03b242\u7b97\u6bd4\u503c\u3002<\/p>\n

\u540c\u4e00\u6b21\u91c7\u8840\u7684\u8840\u6d46\u7b49\u91cf\u5206\u88c5\u540e<\/strong>\uff0c\u8fdb\u884c\u5168\u90e89\u79cd\u8bd5\u5242\u7684\u6d4b\u8bd5\u3002\u91c7\u8840\u7ba1\u548c\u79bb\u5fc3\u7ba1\u7531\u7275\u5934\u4e2d\u5fc3\u7edf\u4e00\u4e0b\u53d1\uff0c1800g\/10min\/4\u2103\u79bb\u5fc3\uff0c\u221280\u2103\u5e72\u51b0\u51b7\u94fe\u96c6\u4e2d\u9001\u5b9e\u9a8c\u5ba4\u3002\u6bcf\u53f0\u4eea\u5668\u7528\u6307\u5b9a\u673a\u53f0\u3001\u540c\u4e00\u6279\u53f7\u8bd5\u5242\uff0c\u6bcf\u4e2a\u4eba\u7684\u6837\u672c\u540c\u4e00\u5929\u5185\u8dd1\u5b8c\u3002\u5b9e\u9a8c\u5ba4\u770b\u4e0d\u5230\u4e34\u5e8a\u4fe1\u606f\uff0c\u533b\u751f\u770b\u4e0d\u5230\u68c0\u6d4b\u7ed3\u679c\uff0cPET\u5224\u8bfb\u4e13\u5bb6\u770b\u4e0d\u5230\u4e24\u8fb9\uff0c\u7edf\u8ba1\u5206\u6790\u4eba\u5458\u5728\u9501\u5e93\u524d\u770b\u4e0d\u5230\u5206\u7ec4\u3002<\/p>\n

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\u5355\u9608\u503c<\/h2>\n

\u6309Youden\u6307\u6570\u53d6\u6700\u4f18cutoff\u3002Quanterix\u548cLychix p-tau217\u51c6\u786e\u7387\u5e76\u5217\u6700\u9ad8\uff0c\u4e3a88.8%<\/strong>\u3002Lychix\u654f\u611f\u6027\u6700\u9ad8\uff0c\u4e3a90.2%<\/strong>\uff0cNPV\u4e3a83.2%\u3002Beckman\u7279\u5f02\u6027\u6700\u9ad8\uff0c\u8fbe\u523093.5%<\/strong>\uff0cPPV\u8fbe\u523095.8%<\/strong>\u3002Quanterix \u7684AUC\u4e3a0.930<\/strong>\uff0c\u6700\u9ad8\uff1bBeckman \u76840.929<\/strong>\u8d34\u8eab\u76f8\u968f\u3002<\/p>\n

\u53e62\u79cd\uff08\u5382\u5bb6A\u3001B\uff09AUC<0.800\uff0c\u548c\u524d\u97627\u79cd\u7684\u76f8\u5173\u6027Spearman \u03c1\u591a\u6570<0.70\u3002<\/p>\n

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\u53cc\u9608\u503c<\/h2>\n

\u5355\u9608\u503c\u628a\u4eba\u4e00\u5200\u5207\u6210\u9634\u9633\uff0c\u9760\u8fb9\u754c\u7684\u4eba\u600e\u4e48\u529e\uff1f\u53cc\u9608\u503c\u7684\u610f\u601d\u662f\uff0c\u4f4e\u4e8e\u4e0b\u9650\u6392\u9664\uff0c\u9ad8\u4e8e\u4e0a\u9650\u786e\u8ba4\uff0c\u4e2d\u95f4\u5c31\u662f\u7070\u533a\u3002<\/p>\n

\u53cc90%\u7684\u76ee\u6807\u4e0b\uff0c\u5206\u7c7b\u51c6\u786e\u738788.2%-89.5%<\/strong>\uff0c\u7070\u533a2.8%-13.7%<\/strong>\u3002Quanterix\u7070\u533a\u4e3a2.8%<\/strong>\uff0c\u6700\u7a84\uff1bLychix 4.0%\uff0cBeckman 4.4%\u3002<\/p>\n

\u53cc95%\u7684\u76ee\u6807\u4e0b\uff0c\u51c6\u786e\u7387\u5347\u523091.7%-93.2%<\/strong>\uff0c\u7070\u533a\u66b4\u6da8\u81f321.1%-35.5%<\/strong>\u3002\u6309\u516c\u8ba4\u768415%-20%\u53ef\u63a5\u53d7\u57fa\u51c6\uff0c95\/95\u4e0b\u6ca1\u6709\u4e00\u79cd\u8bd5\u5242\u8fbe\u6807<\/strong>\u3002\u66f4\u591a\u4eba\u6d4b\u4e86\u7b49\u4e8e\u767d\u6d4b\u3002<\/p>\n

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\u96be\u641e\u5b9a<\/h2>\n

FDA\u6279\u51c6\u7684Fujirebio\uff0c\u6bd4\u503c\u53cc\u9608\u503c\uff0c\u6392\u9664\u7075\u654f\u5ea6\u4e3a99.3%<\/strong>\uff0c\u786e\u8ba4\u7279\u5f02\u6027\u4e3a69.0%<\/strong>\uff0c\u8fd1\u4e09\u5206\u4e4b\u4e00\u7684\u786e\u8ba4\u9633\u6027\u6f0f\u6389\u3002<\/p>\n

Mayo Clinic\u7684\u9608\u503c\uff0892.4%\/89.7%\uff09\u4e0b\uff0c\u7070\u533a11.6%\uff0c\u6700\u5e73\u8861\u3002<\/p>\n

\u5382\u5bb6\u8bf4\u660e\u4e66\u81ea\u5e26\u7684cutoff\u540c\u6837\u7ffb\u8f66\uff0cVazyme\u5355\u9608\u503c\u7279\u5f02\u602775.5%<\/strong>\uff0cLychix\u5355\u9608\u503c\u654f\u611f\u602741.8%<\/strong>\u3002Beckman\uff080.7281 pg\/mL\uff09\u548cQuanterix\uff080.47 pg\/mL\uff09\u504f\u79bbYouden\u6700\u4f18\u53ea\u67092%\u548c3.8%\u3002<\/p>\n

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\u4e0d\u540c\u6297\u4f53+\u4e0d\u540c\u6821\u51c6\u54c1+\u4e0d\u540c\u5e73\u53f0\uff0c\u6027\u80fd\u53ef\u4ee5\u5dee\u51fa\u4e00\u5927\u622a\u3002<\/p>\n

Lv X, Shen K, Zhao Q, et al. Head-to-head comparison of plasma biomarker assays across platforms for amyloid pathology in a multicenter cohort. *Science Bulletin*. 2026. DOI: 10.1016\/j.scib.2026.08.018.<\/p><\/blockquote>\n<\/section>\n

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\u94fe\u9709\u4eb2\u548c\u7d20\u5fae\u7403\u662f\u5982\u4f55\u5236\u5907\u7684\uff1f<\/a><\/p>\n

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\u7a7a\u767d\u9650\u3001\u68c0\u51fa\u9650\u3001\u5b9a\u91cf\u9650\uff0c\u4e00\u7bc7\u5c31\u8ba9\u4f60\u660e\u767d\uff01<\/a><\/p>\n<\/section>\n","protected":false},"excerpt":{"rendered":"

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